Conan O'Brien and Denis Leary are cousins. Denis Leary was born in Worcester, Massachusetts, the son of Irish Catholic immigrants. His mother, Nora, was a maid, and his father, John Leary, was an auto mechanic. As both of his parents are from Killarney, County Kerry, Ireland, Leary holds both Irish and U.S. citizenship. Through marriage, Leary is a third cousin of talk show host Conan O'Brien and his sister Jane O'Brien. He attended Saint Peter-Marian High School, in Worcester.
Conan O'Brien was born in Brookline, Massachusetts. His father, Thomas Francis O'Brien, is a physician, epidemiologist, and professor of medicine at Harvard. His mother, Ruth O'Brien, is an attorney and partner at the Boston firm Ropes & Gray. He is the third of six children. O'Brien's family is Irish Catholic; some of his Irish ancestors immigrated before the American Civil War. In a Late Night episode, O'Brien paid a visit to County Kerry, Ireland, where his ancestors originated.