The 42-year-old from New Jersey, U.S, is set on reaching the 1,000lb mark (71st) in just two years. Remarkably she insists she is healthy, despite now needing a mobility scooter when she goes shopping.
'My favourite food is sushi, but unlike others I can sit and eat 70 big pieces of sushi in one go,' she said.
'I do love cakes and sweet things, doughnuts are my favourite.'
Donna, who wears XXXXXXXL dresses, eats mounds of junk food and tries to move as little as possible.
Ms Simpson already holds the Guinness World Record as the world's fattest mother, when she gave birth in 2007 weighing 38stone.
She needed a team of 30 medics to deliver her daughter Jacqueline during a high-risk Caesarean birth.
Yet although she can only move 20ft before needing to sit down, she wants to be even bigger.
'I'd love to be 1,000lb,' she said.
'It might be hard though. Running after my daughter keeps my weight down.'
You might expect her long-term partner Philippe, 49, to advise her to slim down, but instead he encourages her to eat more.
He met Donna on a dating site for plus-size people and is a self-confessed fat admirer, although he himself only weighs 150lbs.
'I think he'd like it if I was bigger,' said Donna.
'He's a real belly man, and completely supports me.'
To achieve her goal, Donna says she will need to eat up to 12,000 calories a day (the average woman should consume only 2,000.)
To fund the massive $750 weekly food shop, she runs a website where men pay her to watch her eat fast food.
Donna's weight problem began early. Her mother made big meals for Donna and her brothers and gave them lots of treats and fattening food.
By the time Donna was nine, she weighed 13 stone.
'Food was her way of showing she loved us, she wanted us to eat, and she was very protective of us,' Ms Simpson said.
'She wouldn't let anyone say anything bad to us about our weight. She would argue with doctors who said it was dangerous.'
Donna's mother died soon after, and her dad married a woman who put the children on a strict diet.
'I used to steal food from the cupboards, which were still full because my mum used to store food,' she said.
But as she got older, Donna began to worry about her weight and started taking diet pills.
Between the ages 14 and 18 she slimmed down to 11 stone, but was still unhappy.
'Dieting just made me miserable because I was thinking about food all the time.,' she said.
After she left school, Donna got a desk job and no longer felt the need to fit in with other girls.
'I felt so much better when the weight came back,' she said.
'It felt like who I was meant to be.'
When Donna was 19 she met her first husband, who worked as a chef at a steak restaurant.
'He worked night shifts and would come home at 2 or 3am and bring the leftovers with him,' she said.
'We'd stay up and eat huge piles of steak, mashed potatoes, and gravy with butter.
'I started gaining weight quickly and my husband liked it.
'He said I was sexier when I was bigger, and I felt happier too.'
When she was 27, Donna weighed 25 stone, and fell pregnant with her eldest son, Devin. Her marriage ended soon after and she turned to food for comfort.
By the age of 31, she weighed 43 stone and decided to try and lose weight. She lost five stones in six months and was due to have a gastric band operation.
But just before she was due to go under the knife, her friend died during a similar operation.
'That was a sign for me,' Ms Simpson said.
'I decided it just wasn't worth it. I like being the way I am.'
Donna, then 37 stone, came across a website which celebrated obese women.
When she admitted her real size, Donna was flooded with emails from men.
'They sent me gifts through the post, like protein shakes to help me put on weight faster,' she said.
And she unrepentant of her weight-gain goal, despite risking her own life in the process.
'I love eating and people love watching me eat,' she said.
'It makes people happy, and I'm not harming anyone.'
Read more: http://www.dailymail.co.uk/health/article-1257850/Super-sized-mother-determined-worlds-fattest-woman-years.html#ixzz1t7lRqwpm
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